Wednesday, June 5, 2013

What Is Ollier's Disease?

Ollier's disease is a rare nonhereditary sporadic disorder that occurs in 1 in 100,000 people. It presents as
intraosseous benign cartilaginous tumors that develop close to growth plate cartilage. It is not clear if the disease is caused by a single gene defect or a combination of mutations, but the irregular distribution of tumors suggests that the disease is a result of mosaicism, or error in cell division that occurs before birth.
The disorder, named after French surgeon surgeon Louis Leopold Ollier, consists of numerous endochondromas which develop during childhood. The growth of these endochondromas usually stops after you have reached your full height, but the affected extremity is often shortened and bowed due to epiphyseal fusions. Those with Ollier's disease are prone to breaking bones, have enlarged toes, a bony mass on the toe, and complain of swollen, aching limbs. Ollier's disease typically affects just one side of the body and can transform into a malignant sarcoma. The hands and feet are most affected by Ollier's disease. Sometimes injury or trauma to the toe will result in the formation of the bony irregularity or prominence.
On an X-ray, streaks of low density will be seen on the long bones due to ectopic cartilage deposits. Over your lifetime, this cartilage will calcify in a snowflake pattern. Ollier's disease is often not diagnosed until the patient fractures a bone in their foot and the endochondromas appear on the X-rays.
Only when the tumors are aggressive and destroy bone tissue will they require further treatment. Pain when at rest is also a clue treatment is needed, as it is a sign of malignancy. Surgery can be done to remove the painful and problematic endocondromas. During surgery bone grafts are used to fill the cavity caused from removing the endochondroma.
If you have a foot deformity, call our Glastonbury or Middletown office to make an appointment.
Ayman M. Latif, DPM
Connecticut Foot Care Centers
Foot Deformity Doctor in CT
Podiatrist in Glastonbury and Middletown, CT
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